【課題】正常眼圧緑内障疾患感受性遺伝子及びその利用方法を提供する。
【解決手段】多数の正常眼圧緑内障患者と正常人を対象に全ゲノム上の一塩基多型を網羅的に解析・比較し、一塩基多型国際番号rs222450、rs9474394、rs2816344、rs2816341等の複数の国際番号に代表されるヒト第６染色体のELOVL5を含む領域の多型部位などに相違を見出した。これらの多型部位の相違に基づいて、正常眼圧緑内障の診断が可能となる。

【特許請求の範囲】
【請求項１】
ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位（但し、一塩基多型国際番号rs3213787及びrs17832851を除く）の塩基を同定することを含む、正常眼圧緑内障の検査方法。
【請求項２】
ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs222450、rs9474394、rs2816344、rs2816341、rs2518579、rs2518578、rs9367511、rs6915699、rs6930045、rs9370188、rs9382180、rs9382181、rs4486010、rs2816379、rs6939730、rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs10948744、rs12183976、rs2562898、rs735860、rs715441、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201、rs9367529、rs12209741、rs7744451、rs6904083、rs6904376、rs9367532、rs2067833、rs9382212、rs2139077、rs2397146、rs7742367、rs9474576、rs622447、rs3736729、rs13212365及びrs761141からなる群より選択され、
ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs11686431、rs7580559、rs3908093、rs2343412、rs12623996、rs7573149、rs918810、rs6721199、rs7579209、rs10194925、rs17033378、rs2343466、rs17033398、rs6737172、rs4953226、rs3851333、rs12473388、rs11681887、rs35608719、rs11888802、rs11678872、rs2343468、rs13003019、rs6760244、rs12471726、rs2081297、rs10460504、rs7562458、rs4953230、rs4952763、rs6719211、rs1014454、rs3755070、rs10210691、rs3770251、rs4455206、rs3755076、rs3770254、rs11125017、rs3770264、rs10205197、rs10427308、rs17033745、rs3770278、rs17322370、rs6736954、rs10427402、rs4476395、rs13023749、rs17033801、rs755652、rs748573、rs6708810、rs6710581、rs12712945、rs17033871、rs3755082、rs6544840、rs7599740、rs11884064、rs7596942、rs7565326、rs17323037、rs1916231、rs1517001、rs1522988、rs614281、rs582213、rs650508、rs666334、rs17033965、rs556650、rs2204204、rs3795863、rs2285024、rs505310、rs10490342、rs612717、rs10490341、rs656823、rs563601、rs609573、rs6746467、rs637889、rs10495926、rs1522986、rs1522987、rs6544843及びrs6724488からなる群より選択され、
ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs1523048、rs1523029、rs12487524、rs1403468、rs872133、rs1523040、rs1523041、rs13069451、rs12629480、rs1357449、rs6801949、rs17033355、rs9873254、rs9839823、rs6794354、rs6794373、rs12637211、rs9855328、rs2037538、rs2037539、rs1523038、rs11718271、rs1608314、rs2197728、rs9311101、rs10490870、rs17033506、rs12634096、rs2359774、rs9860326、rs4678788、rs3213953、rs6799641、rs17201627、rs4678789、rs12632607、rs11129660、rs11129662、rs17033672、rs17280201、rs6779091、rs3772395、rs9872664、rs1963934、rs35102908、rs4678802、rs4678803、rs6550367、rs17033738、rs6801590、rs17033748、rs9865772、rs17033755、rs17228111、rs2016955、rs2016975、rs735353、rs11920715、rs1378481、rs17814981、rs1455489、rs4678509、rs10510667、rs6799649、rs6799609、rs17033836、rs4234248、rs6770245、rs10865865、rs7615307、rs9845811、rs17033961、rs1488092、rs10461001及びrs17033999からなる群より選択され、
ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs170654、rs1514271、rs2063419、rs13102419、rs11131589、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs4860651、rs11938753、rs1376417、rs10025570、rs1376416、rs2084682、rs7658065、rs9312144、rs1376412、rs17086181、rs17086185、rs6847413、rs2198103、rs12509018、rs17082122、rs6823779、rs17086224、rs1451170、rs4289492、rs4371663、rs9986026、rs9991256、rs4267782、rs7660334、rs6815080、rs11737314、rs4365778、rs7673091、rs4320185、rs4604104、rs7684022、rs4860679、rs6844942、rs12644315、rs4599467、rs6834811、rs4320186、rs4487412、rs7667410、rs4611975、rs4370201、rs4438803及びrs4608860からなる群より選択され、
ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs11966212、rs2143396、rs6911992、rs9378593、rs9392253、rs9378594、rs2050158、rs9391900、rs6596786、rs2235706、rs9378596、rs1997773、rs6926322、rs7754106、rs7750178、rs742520、rs2210370、rs6940618、rs349100、rs9405444、rs6932005、rs4959523、rs10484953、rs464778、rs115705、rs1013185、rs11242672、rs463641、rs4959525、rs369656、rs459162、rs127091、rs4959530、rs463264、rs7757477、rs448915、rs444018、rs443971、rs9391913、rs238048、rs238050、rs9378605、rs2459602、rs2438074、rs12191625、rs2438077、rs2496292、rs2496301、rs2438083、rs977674、rs977673、rs17259747、rs1437288、rs7772349、rs6596805、rs1347656、rs6925983、rs1550199、rs11242676、rs7744559、rs11966550、rs9378290、rs9405136、rs9405470、rs9392285、rs9405137、rs9405471、rs746095、rs9378623、rs9378292、rs1711957、rs7742720、rs9378629、rs7741690、rs9328052、rs9328053、rs1922938、rs2745636、rs2816242、rs932410、rs1474721、rs9392296、rs9502950、rs6907725、rs9405484、rs4443540、rs4355648、rs9328058、rs9328059、rs2569866、rs6935712、rs6935896、rs6937266、rs6925228、rs11242704、rs2816286、rs2816287、rs6596833、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs2317966、rs9392305、rs9501738、rs2569839、rs9328061、rs9378300、rs2816221、rs6916316、rs2281272、rs2569824、rs9405496、rs1810496、rs2814827、rs7759035、rs9502997、rs2814811、rs2317964、rs9378304、rs2569854、rs12206340、rs4538755、rs9378305、rs9503011、rs9405505、rs9503015、rs9501762、rs9405506、rs12197419、rs7765344、rs7765461、rs1013303、rs3800046、rs689035、rs2318108、rs6919059、rs6928276、rs226456、rs9378314、rs1157673、rs1157675、rs9391933、rs9328071、rs3778533、rs1028714、rs3800094、rs3778539、rs6596857、rs7776397、rs6596858、rs9378661、rs3823279、rs3800122、rs10484693、rs17772389、rs4959160、rs3778555、rs4463305、rs3800140、rs17134506、rs3800142、rs3800143、rs3800144、rs3800146、rs2761234、rs9405156、rs17134549、rs1408002、rs1830733、rs1830734、rs10223785、rs9405157、rs7772545、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs12212324、rs9392353、rs11242730、rs4580917、rs6910252、rs11242733、rs9503080、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs17134693、rs3800156、rs11242740、rs4959635、rs3800159、rs3778557、rs3800168、rs4959642、rs234930、rs9392372、rs234915、rs234914、rs3800184、rs234932、rs6903476、rs3778568、rs9405550、rs17134819、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs4413658、rs7449538、rs9503158、rs6902556、rs6925653、rs4281006、rs12210286、rs12213061、rs4959663、rs9501836、rs6911665、rs13200914、rs17135028、rs4959184、rs11242770、rs9328099、rs12206851、rs6904395、rs17609498、rs742487、rs4959185、rs9391949、rs9391950、rs6899721、rs1610416、rs3924452、rs10458144、rs9501850、rs9503199、rs4959677、rs35374935、rs2449448、rs1772982、rs1680885、rs2794569、rs2624936、rs12196957、rs2624933、rs1773000、rs1773001、rs1614248、rs1616044、rs2624917、rs2624916及びrs6899711からなる群より選択され、
ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2248373、rs2248459、rs2248462、rs2248617、rs3749946、rs2523650、rs2904776、rs2516422、rs2905747、rs9267247、rs2395034、rs3095229、rs3131631、rs2516486、rs2734573、rs3115537、rs2516478、rs2071593、rs3219183、rs13215091、rs1799964、rs1052248、rs9348876、rs2857697、rs2736172、rs1046089、rs2255741、rs760293、rs2077102、rs3130048、rs2844463、rs805301、rs805300、rs805297、rs707921、rs2242655、rs707974、rs805268、rs805267、rs9378164、rs707918、rs805292、rs2299851、rs707939、rs707937、rs480092、rs2075800、rs2763979、rs11965547、rs486416、rs644045、rs537160、rs2072633、rs522162、rs550513、rs9296003、rs406936及びrs492899からなる群より選択され、
ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs602698、rs678116、rs649930、rs643677、rs592698、rs675053、rs612557、rs629364、rs627967、rs628203、rs2771425、rs9355655、rs10499309、rs1041566、rs12530454、rs7753885、rs9347236、rs6455585、rs6931414、rs10447366、rs9457403、rs9355246、rs4709219、rs4708797、rs4709226、rs4709235、rs6925091、rs3799195、rs6913912、rs894124、rs6903405、rs6901469、rs9364496、rs7759006、rs6455600、rs2129209、rs6455601、rs9456350、rs3123094、rs9456352、rs3102970、rs6455604、rs3127188、rs3127194、rs3127196、rs3102966、rs3127168、rs923198、rs6924755、rs2361472、rs4569991、rs9457516、rs9456363、rs9365009、rs3923902及びrs12207795からなる群より選択され、
ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs3807826、rs7802863、rs3757521、rs3757520、rs3807823、rs1861032、rs17145870、rs7805508、rs6977682、rs3807815、rs1008038、rs3807811、rs11769978、rs3779356、rs3807807、rs3807806、rs7455929、rs6463790、rs4620183、rs12668479、rs17147407、rs11762595、rs12702719、rs17147608、rs12154895、rs17403198、rs16873367、rs42949、rs2349188、rs6463805、rs7811039、rs10247446、rs10270530、rs7795595、rs6945018、rs17148966、rs1476623、rs10246412、rs17404198、rs6463813、rs17149337、rs17404218、rs11976158、rs10244689、rs6978212、rs757704、rs2214694、rs2189904、rs765855、rs17150199、rs10261060、rs4401754、rs10266489、rs5018942、rs4556000、rs10278603、rs7787432、rs6959052、rs17150410、rs17150472、rs17150479、rs17150761、rs10237485、rs4720785、rs972247、rs1859274、rs10238726、rs6970999、rs17151821、rs7456267、rs6963180、rs10257265、rs970526、rs977458、rs13240427及びrs17154007、並びにNCBI(v36.1)8484291からなる群より選択され、
ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs41521、rs2188486、rs977641、rs17389507、rs10274138、rs17136882、rs13234807、rs7794181、rs7787988、rs7787976、rs17331134、rs1557689、rs6465984、rs7798273、rs2188494、rs1468143、rs10953427、rs2214087、rs4730006、rs6952170、rs17137313、rs4727599、rs17137382、rs10228106、rs42181、rs4730010、rs11763758、rs17137711、rs11763095、rs6977743、rs4520098、rs10216261、rs11972050、rs12539136、rs756669、rs41037、rs41038、rs28253、rs41058、rs9649272、rs6949801、rs9987005、rs6465994、rs6465995、rs1477110、rs12216618、rs10254402、rs6969323、rs9641335、rs10272959、rs3919550、rs4730030、rs10246540、rs4730031、rs2891730、rs995661、rs10487221、rs10487222、rs11773248、rs11983223、rs6943307、rs7782065、rs7801387、rs12705261、rs12531723、rs17269890、rs4730038、rs4584085、rs10216010、rs17141284、rs17141299、rs10953450、rs6466018、rs4530975、rs12705276、rs4283980及びrs2470965、並びにNCBI(v36.1) 103849313、104068646及び104196627からなる群より選択され、
ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs470713、rs470935、rs641024、rs11606866、rs7131644、rs10894784、rs1031381、rs522134、rs4362160、rs473041、rs498602、rs554874、rs1144225、rs1595895、rs1146192、rs4936229、rs1144219、rs2510356、rs553231、rs512359、rs568044、rs10894798、rs10894799、rs11223765、rs10894800、rs7940114、rs10894801、rs10791357、rs3741100、rs3741098、rs7113199、rs1866769、rs1866768及びrs1561613からなる群より選択され、
ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs3794941、rs17055278、rs514931、rs494721、rs17055426、rs2896769、rs12717033、rs7227977、rs10871527、rs10514139、rs17055756、rs1473224、rs2628125、rs8085262、rs8089151、rs2628123、rs4891199、rs17055919、rs10514148、rs17055185、rs2404482、rs10514149、rs4337381、rs2959165、rs12456768、rs4891217、rs9945585、rs9961644、rs9961742、rs9952375、rs13381156、rs9319675、rs2120144、rs8096648、rs17056218、rs2289609、rs4891228、rs1396098、rs894575、rs10871567、rs7242893及びrs7239800からなる群より選択され、
ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs3000058、rs2816030、rs16862061、rs2816040、rs2816046、rs4920334、rs4920516、rs4920335、rs2816064、rs6704504、rs1934057、rs2298893、rs2743208、rs2076021、rs2076020、rs2236826、rs2282704、rs2282699、rs624761、rs851123、rs2236817、rs685300、rs2056446、rs2841078、rs4920344、rs6669544、rs4076925、rs6603910、rs11261070、rs7539659、rs11261074、rs7411058、rs4920545、rs6684577及びrs12565195からなる群より選択され、
ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs2494997、rs1999674、rs2842180、rs2255632、rs2251804、rs1334973、rs6687571、rs2039528、rs2819341、rs10890251、rs2367617、rs11210864、rs2782641、rs11210871、rs10890257、rs12058744、rs11210879、rs11210886、rs516790、rs641365、rs673485、rs643445、rs10789438、rs11210892、rs617521、rs660899、rs2274465、rs10789439、rs489319、rs607062、rs10789442及びrs3791035、並びにNCBI(v36.1)43760103からなる群より選択され、
ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200rs12122453、rs12122534、rs4950474、rs4950475、rs6593810、rs6657631、rs21327、rs517201、rs575115、rs2031481、rs2477568、rs2477569、rs692963、rs535827、rs4950361、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs2077749、rs17159914、rs6593745、rs2120003、rs10900325、rs2354432、rs6670503、rs1470261、rs6703187、rs10793652、rs7537483、rs7537703、rs1890038、rs3820130、rs3737845、rs17160062、rs3766525、rs4950315、rs17356240、rs10494244、rs6683839、rs10793656、rs17360443、rs3753433、rs12033407、rs7554833、rs10793661、rs10736837、rs10900336、rs7520661、rs4950409、rs2353983、rs6658836、rs17360812、rs6656156、rs12759145、rs12049491、rs10793682、rs4950431、rs7539416、rs2353969、rs4504949、rs17160205、rs2353967、rs12728058、rs6688308、rs11589438、rs6688154、rs6678706、rs4950436、rs7519891、rs11240053、rs11240054、rs11240055、rs7556087、rs7518276、rs2644579、rs2353951、rs2644577、rs6674761、rs2644566、rs2803535、rs17160256、rs12406844、rs17160264、rs612963、rs586000、rs17160295、rs644550及びrs17160305からなる群より選択され、
ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs10752613、rs11583896、rs16835600、rs4434872、rs4567311、rs4363451、rs9427232、rs4845576、rs4520447、rs4845578、rs11585416、rs4845584、rs12033835、rs11581644、rs10908557、rs6701341、rs2297898、rs12048137、rs11264875、rs2066134、rs2494663、rs6671166、rs4845600、rs16835819、rs4521985、rs4620534、rs9803857、rs11265310、rs2340473、rs1194596、rs1212352、rs6672010、rs6702754、rs2274988、rs2297607、rs4414034、rs6696089、rs11265607、rs6427631、rs6427658、rs6694817、rs4537545、rs4845626、rs11265618、rs10752641、rs4240872、rs4474240、rs6700296、rs11265627、rs6691727、rs6687112、rs6427716、rs12136771、rs7553602、rs6660775、rs1127314、rs1127313、rs2131902、rs2229857、rs3766923、rs3766922、rs12125166、rs2335230、rs7531982、rs7533471、rs11264233、rs10796927、rs2335252、rs2036627、rs6699979、rs1995662、rs6664817、rs11264249、rs6426905、rs960182、rs16836320、rs868108、rs4845390、rs10494300、rs1051614、rs6666341、rs11808053、rs883319、rs1777910、rs951240ｖ、rs951241、rs9970364、rs1984285、rs6681725、rs16836414、rs10796934、rs10908445、rs4845678、rs4845679、rs4845681、rs12130132、rs10908448、rs4845690、rs4845406、rs10908455、rs7368345、rs10908456、rs4971079、rs4276913、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822519、rs822508、rs1749405、rs1749409、rs572609、rs3768280、rs2275078、rs2016251、rs1475766、rs12035615、rs4661146、rs6700693、rs10908489、rs11264449、rs2253677、rs2241110、rs2853641、rs2075163、rs2241107、rs1052053、rs1052067、rs759330、rs7542798、rs2253358、rs2842880、rs16837272、rs2287023、rs2246476、rs2248273、rs11264467、rs7522860、rs10908500、rs10494304、rs3795730、rs3762281、rs35478936、rs2274226、rs2985714、rs2842854、rs954916、rs6686886、rs11590409、rs4661040、rs7551781、rs16837376、rs11806983、rs1109751、rs11264486、rs3790458、rs1342442、rs12136856、rs10159180、rs1171564、rs1609666、rs728918、rs11264495、rs744224、rs4661184、rs879461、rs12742817、rs3795736、rs2236601、rs1046650及びrs3795737からなる群より選択され、
ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs7521610、rs16850728、rs227521、rs227519、rs10047146、rs10489307、rs972484、rs1402640、rs10913291、rs12094495、rs10798503、rs6425414、rs7515582、rs10913294、rs7534953、rs10913295、rs725416、rs12090000、rs12564343、rs12031932、rs12079554、rs554454、rs6660903、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs16851037、rs17315298、rs2861972、rs1883243、rs6660559、rs4652245、rs4140633、rs7528533、rs3946142、rs6658794、rs9425456、rs6672376、及びrs12025407からなる群より選択され、
ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1122396、rs1722755、rs6413916、rs831771、rs1404401、rs831767、rs16847944、rs831765、rs16847947、rs831764、rs16847951、rs831762、rs831753、rs16847994、rs831751、rs4915220、rs10157719、rs947379、rs12466、rs1592085、rs4915499、rs12134467、rs10158798、rs1954214、rs12046907、rs10920161、rs12117501、rs1997018、rs1880450、rs1857489、rs16848184、rs868381、rs854488、rs832169、rs832174、rs700469、rs860554rs1779301、rs2300293、rs2268156、rs832147、rs854502、rs1722780、rs1779293、rs854505、rs1572968、rs17425876、rs12143423、rs947377、rs10753899、rs17459837、rs6427900、rs1122481、rs2275862、rs11806184、rs2365652、rs2275860、rs947485、rs6671391、rs1256941、rs10800779、rs7553988、rs10920205、rs3887566、rs3888929、rs6427908及びrs12090950からなる群より選択され、
ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs2577720、rs2723120、rs10495742、rs2577717、rs6720565、rs12053097、rs12613333、rs7566157、rs17045229、rs875077、rs17045238、rs2723129、rs2577698、rs2954818、rs12989910、rs11125011、rs6742888、rs7564616、rs2723111、rs6544822、rs893430、rs737564、rs737565、rs747344、rs6727901、rs7570872、rs17045350、rs6544861、rs6756357、rs4665214、rs10172684、rs1653748、rs1465677、rs1864807、rs1864808、rs4665218、rs10169643、rs1368080、rs10490750、rs11677730、rs7601971、rs1653751、rs1653753、rs1368081、rs11678782、rs11678785、rs4497835、rs1653780、rs17445645、rs4665223、rs4284788、rs4665612、rs1709339、rs6544949rs17045574、rs6544966、rs4665230、rs583168、rs17045705、rs2280122、rs1548020、rs518113、rs497973、rs3806510、rs13386930、rs6721623、rs3795933、rs7560892、rs4233701、rs9261、rs7579413、rs12470949、rs12478701、rs2081302、rs12478744、rs2339853及びrs35379186からなる群より選択され、
ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6765461、rs6801153、rs1464010、rs7630879、rs6550848、rs826375、rs1667765、rs826378、rs6808673、rs2596623、rs17194828、rs1562736、rs9310730、rs2683535、rs7652337、rs7652444、rs2683542、rs1667739、rs1505302、rs6799431、rs17014338、rs826249、rs10510540、rs6772213、rs851719、rs6792783、rs1354605、rs866651、rs958892、rs826225、rs6550853、rs826223、rs826218、rs1466122、rs1449874、rs11719336、rs7625917、rs17787283、rs4858594、rs1449872、rs9849581、rs9863517、rs9843698、rs9867989、rs1667746、rs17787319、rs1505307、rs7640580、rs12639035、rs9810037、rs9833191、rs12630454、rs3951794、rs6781111、rs1505287、rs12495379、rs4858608、rs7624363、rs4640503、rs6550865、rs9839986、rs5014281、rs9831450、rs4241527、rs4858617、rs4858618、rs2196427、rs10490840、rs6788339、rs6765048及びrs892941からなる群より選択され、
ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs13088412、rs9837084、rs744876、rs571170、rs358954、rs9833515、rs6440716、rs358967、rs1993404、rs9883677、rs2048229、rs16863149、rs891666、rs1835668、rs6787683、rs16863204、rs16863208、rs16863229、rs3732755、rs3773614、rs1231521、rs3108727、rs3773619、rs7649855、rs16863264、rs2870518、rs3846072、rs6782715、rs1882014、rs16863287、rs10513391、rs3773621、rs10935835、rs9863821、rs9864095、rs1873619、rs7623356、rs1491981、rs6440735、rs3971192、rs7644001、rs16863323、rs6801273、rs9820422、rs16863336、rs1388622、rs3975404、rs10513394、rs6787801、rs9289836、rs3821663、rs7429509、rs3821664、rs1491974、rs9653953、rs17204501、rs17204508、rs4680406、rs12490051、rs16863364、rs11708767、rs11709550、rs3732769、rs10935844、rs2276765、rs2276766、rs16863376、rs6440741、rs6771904、rs6772196、rs3732771、rs9864533、rs4435614、rs17204557、rs6798252、rs4680440、rs4680443、rs13088575、rs6790903、rs9289840、rs4680474、rs4541381、rs4596123及びrs7612205、並びにNCBI(v36.1)152200518、152229595、152456055及び152609183からなる群より選択され、
ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10866277、rs12645545、rs12649063、rs7437897、rs11132327、rs10866278、rs6823490、rs6843640、rs6818789、rs2101307、rs6552895、rs6552896、rs6552897、rs12498673、rs10025265、rs2306707、rs3749579、rs6848934、rs2306703、rs11934819、rs4862558、rs4599460、rs4862559、rs6823546、rs11132334、rs5018568、rs904451、rs7677363、rs2030144、rs11132338、rs11132340、rs7669883、rs6858544、rs1027521、rs2173480、rs2173479、rs11132344、rs10084919、rs7677532、rs6835720、rs10024805、rs6834923、rs6812818、rs10015164、rs11132345、rs10024359、rs10000785、rs1039235、rs2310357、rs10028428、rs4862571、rs7684943、rs10021308、rs1566347、rs12504307、rs11132355、rs10028944、rs1499010、rs11724690、rs11940307、rs1566354、rs2648126、rs2648120、rs2648117、rs2648112、rs4861686、rs1026362、rs12643549、rs2310372、rs4862588、rs10031442、rs4637445、rs1947455、rs2278938、rs12641600、rs4862600、rs10002339、rs7694098、rs830829、rs830838、rs830841、rs2603731rs7697039、rs7697051、rs1356672、rs7679967、rs4861696、rs1519320及びrs12643213からなる群より選択され、
ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs7733618、rs12514219、rs4532318、rs6861487、rs7700850、rs4587034、rs7705086、rs16895307、rs16895308、rs6890124、rs4339298、rs4613646、rs6862416、rs4532319、rs10515011、rs16895357、rs7732647、rs4355471、rs4554157、rs12055346、rs16895417、rs17210621、rs7706654、rs6864239、rs6896102、rs4374700、rs16895456、rs6880657、rs6863239、rs16895458、rs11953193、rs10940078、rs4446417、rs9791090、rs33721、rs33728、rs2548712、rs33696、rs257711、rs33724、rs26384、rs7704890、rs7725568、rs30729、rs26383、rs27637、rs26382、rs9918275、rs258082、rs257699、rs257700、rs16895719、rs30731、rs16895744、rs1835136、rs36157、rs36155、rs544158、rs36144、rs36143、rs26923、rs16895768、rs463219、rs16895790、rs26921、rs192295、rs26929、rs26928、rs461702、rs460844、rs455938、rs464881、rs456775、rs154620、rs17217092、rs154618、rs10056426、rs152407、rs37568、rs734828、rs2280174、rs16896071、rs40206、rs706701、rs17218390、rs6863305、rs39664、rs34691、rs34693、rs10044452、rs34698、rs34699、rs4016246、rs1159201、rs2662227、rs27206、rs469300、rs467845、rs2545396、rs16896246、rs16896295、rs17221226、rs2287929及びrs16896325、並びにNCBI(v36.1)65944399からなる群より選択され、
ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs34896、rs34897、rs3777220、rs3777217、rs11738579、rs3777213、rs7736948、rs6556883、rs9314160、rs6876015、rs11135436、rs17085165、rs17085170、rs10040697、rs6884979、rs7702848、rs2080947、rs10476660、rs154454、rs147295、rs17085249、rs11741590、rs3777194、rs2270554、rs3777190、rs3777188及びrs4642392、並びにNCBI(v36.1)95206085からなる群より選択され、
ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs2913384、rs173423、rs244654、rs824854、rs824848、rs1095103、rs403334、rs10515769、rs2112262、rs33196、rs17056089、rs2042875、rs3843489、rs1541649、rs17056186、rs2116727、rs10067813、rs7709065、rs17056205、rs1368298、rs4704963、rs10070743、rs4704967、rs10056564、rs6875710、rs17643057、rs6883655、rs891903、rs10054046、rs6556373、rs4921537、rs6556377、rs13180086、rs6556379、rs6556381、rs1544754、rs883540、rs17056426、rs17056435、rs1363561、rs9313797、rs1422672、rs17056474、rs17717829、rs10515787、rs10515786、rs10515789、rs9637861、rs7442845、rs12659540、rs3862065及びrs270661からなる群より選択され、
ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs4493692、rs3797712、rs3797713、rs264881、rs36101422、rs264834、rs6879467、rs6883997、rs7721990、rs7713640、rs900464、rs264846、rs2161404、rs2306560、rs3816764、rs11134586、rs12515906、rs264844、rs2279318、rs264843、rs10063658、rs4867879、rs17736846、rs264838、rs12658902、rs2306558、rs262865、rs262840、rs262841、rs262842、rs155239、rs262848、rs262851、rs4867572、rs262852、rs746468、rs90213、rs17051884、rs262860、rs262859、rs10076580、rs6875474、rs185532、rs17669613、rs1013193、rs17669636、rs966595、rs17669654、rs13171272、rs261612、rs13163565、rs17737323、rs155074、rs261016、rs261597、rs166368、rs261633、rs10054135、rs261624、rs261625、rs17560224、rs4867895、rs168678、rs30080、rs30083、rs17670092、rs7717087、rs17737597、rs7729471、rs261039、rs261038、rs1482333、rs2291229、rs261021、rs261076、rs12515095、rs17646198、rs17560405、rs261067、rs261060、rs261006、rs261008、rs11740615、rs11741667、rs155023、rs11742527、rs978914、rs12522080、rs2624252、rs6896240、rs6862278、rs3860755、rs259897、rs259899、rs259900、rs259902、rs259903、rs6895199、rs259916、rs12659898、rs1422695、rs17738158、rs17561105、rs11134600、rs6893165、rs2161366、rs9313476、rs17738326、rs2287727、rs17738444、rs6884677、rs13152920、rs9790867、rs11134603、rs17738530、rs2134151、rs12055169、rs17738584、rs1316638、rs17072023、rs13361200、rs17738710、rs10462994、rs10462995、rs6890267、rs6871764、rs17671355、rs6555884、rs17562083、rs10516070及びrs955078からなる群より選択され、
ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs1044043、rs10484565、rs241438、rs1800454、rs241429、rs241427、rs4711312、rs2071482、rs4148882、rs12529313、rs9276815、rs20547、rs9276825、rs9276832、rs241404、rs241403、rs3101942、rs241400、rs3132132、rs151719、rs1050391、rs9378127、rs188245、rs3129305、rs176248、rs12216336、rs2894311、rs12191230、rs2395301、rs12192713、rs12199692、rs1044429、rs592625、rs399604、rs365066、rs3763341、rs4713603、rs4713604、rs6936620、rs2116264、rs1367731、rs439852、rs446853、rs9296069、rs440841、rs3128952、rs3130180、rs3097662、rs3128955、rs3130588、rs9277183、rs3097669、rs9277194、rs376877、rs6457710、rs3077、rs9348904、rs9296073、rs2856816、rs3135021、rs1431403、rs9277542、rs3128963、rs3128965、rs3128966、rs3117229、rs2068204、rs2179920、rs2295120、rs3117242、rs3128921、rs3128923、rs9296079、rs3117230、rs3128930、rs872956、rs9380343、rs6937034、rs6937061、rs9277637、rs3117039、rs3130233、rs3117016、rs2395351、rs3116985、rs3129249、rs3129248、rs1003979、rs2071025、rs2855459、rs439205、rs213208、rs461338、rs458679、rs455567、rs14398、rs3130267、rs3130014、rs211455、rs211453、rs10807124、rs411136、rs2772376、rs7747216、rs9469491、rs17627049、rs210137、rs9296095、rs210138、rs444697、rs1794681、rs9469529、rs4711332、rs12205634、rs1408711、rs1536041、rs2229637、rs10947427、rs3818527、rs3818528、rs3818530、rs4713659、rs594223、rs7759668、rs626156、rs498114、rs654682、rs16869412、rs10947432、rs3818532、rs9394163、rs12203688、rs4713670、rs4713671、rs622917、rs12189725、rs877187、rs4713674、rs4713677、rs943466、rs943467、rs755495、rs747692、rs943475、rs6929696、rs3806108、rs3828783、rs3763253、rs9366829、rs9394169、rs4713686及びrs10947441からなる群より選択され、
ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs1338657、rs9485685、rs9377361、rs9377365、rs9377366、rs9322660、rs9322661、rs2399802、rs17063309、rs680011、rs9499111、rs9404214、rs1569366、rs1569367、rs17443301、rs17063399、rs6906578及びrs7740643、並びにNCBI(v36.1)102984444からなる群より選択され、
ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs1156490、rs6462540、rs1419842、rs2392267、rs1419803、rs1419805、rs1419809、rs6977125、rs17169769、rs17169771、rs7778512、rs1419840、rs35114106、rs1019089、rs16878925、rs1362172、rs2392270、rs17831435、rs10951417、rs1468559、rs10486643、rs6951496、rs7458608、rs2893480、rs4723375、rs1419863、rs1419864、rs9639694、rs9639695、rs10951418、rs10215667、rs6971556、rs12673387、rs4723377、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs12672624、rs10486649、rs2893482、rs12672538、rs10486650、rs2392274、rs2079509、rs10243426、rs2097960、rs1362173、rs1458549、rs450463、rs1023555、rs1023556、rs2530548、rs2530549、rs2530550、rs1419794、rs2530565、rs1458544、rs2609226、rs9792042、rs2530567、rs2609218、rs323925、rs323912、rs10239860、rs1419791、rs17777040、rs17198254、rs17777663、rs17777675、rs17198982、rs17788843、rs324978、rs324981、rs324983、rs1419780、rs325464、rs17199659、rs17789420、rs17789642、rs17170015、rs17200455、rs10263313、rs17790181及びrs11768189からなる群より選択され、
ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs10277512、rs4720221、rs7787226、rs10951500、rs10274668、rs10255208、rs2006882、rs2392472、rs756507、rs2241152、rs7785934、rs7782979、rs17170754、rs3807162、rs3734948、rs741302、rs2041801、rs6966276、rs4723592、rs11769038、rs4723598、rs1882080、rs4723601、rs11982286、rs1986619、rs1882082、rs10268319、rs17170799、rs6957979、rs10225164、rs2293628、rs999744、rs17170820、rs17170826、rs17170830、rs1364373、rs13233995、rs6971267、rs7809487、rs1035582、rs2541103、rs2541074、rs2541075、rs2551069、rs1420421、rs6958656、rs10257460、rs12666532、rs1420422、rs17170915、rs10224438、rs7809365、rs6963276、rs6967358、rs6967403、rs10279544、rs4723619、rs17170955、rs2723969、rs6944921、rs6462746、rs1016321、rs2541082、rs4723631、rs2541089、rs2717975、rs10238916、rs2723952、rs12534004、rs2893540、rs2724006、rs2717983、rs2717990、rs2701004、rs2724007、rs2717992、rs2723996、rs9655380、rs2701003、rs2717993、rs2724003、rs2723980、rs2723990、rs2717948、rs2700992、rs6462758、rs2724014、rs2724016、rs1882079、rs2717954、rs13247953、rs2392495、rs10233634、rs12532031、rs4720246、rs7782999、rs1425124、rs1647801、rs2052688、rs2052687、rs10282309、rs10239693、rs17261508、rs10267165、rs918979、rs7777258、rs11767227、rs1647791、rs1732001、rs17171045、rs9655382及びrs6952260、並びにNCBI(v36.1)37495022からなる群より選択され、
ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs12680471、rs2085640、rs17149989、rs17730481、rs17663071、rs17663167、rs4841147、rs1458938、rs1458939、rs11786942、rs17674819、rs1466338、rs13253327、rs17150066、rs11777274、rs11249921、rs17150087、rs1380104、rs11997346、rs4841156、rs6991328、rs17150131、rs7817148、rs10100760、rs17150181、rs17150185、rs17733293、rs7835349、rs7013746、rs7016636、rs3989158、rs17150211、rs4841169、rs4841171、rs6985564、rs11991621、rs4840426、rs6992432、rs10503380、rs7013834、rs6980831、rs12681719、rs4840427、rs4841179、rs7832096、rs4474027、rs4457339、rs12674762、rs4535743、rs1393、rs4342598、rs11780274、rs13273033、rs4841197、rs7010270、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs11785739、rs17150478、rs11787443、rs2898223、rs7820917、rs7829463、rs7000483、rs1567837、rs17734290、rs12540961、rs7829733、rs2137790、rs13249584、rs7013686、rs7015101、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996、rs7828229、rs17150703、及びrs531564からなる群より選択され、
ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs12549261、rs10955436、rs6981257、rs11774921、rs11781710、rs1954724、rs6997025、rs1892764、rs16875775、rs11778352、rs2584372、rs2246255、rs2022958、rs2022949、rs16875901、rs1010824、rs2507799、rs10505100、rs11777978、rs16875983、rs9297393、rs7009229、rs13257393、rs4077322、rs11997995、rs10505105、rs4133396、rs4133395、rs4341141、rs10505107、rs11780324、rs35143736、rs17368715、rs17296616、rs17368821、rs10955450、rs1433178、rs2514850、rs1283653、rs2445351、rs1283659、rs16876122、rs1632130、rs1672143、rs16876200、rs2514867、rs1283706、rs1283703、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191、rs1298936、rs1368497、rs1529747、rs2916085、rs1368494、rs3847160、rs1654680、rs17301273、rs10086467、rs16876325、rs1283720、rs1433171、rs1433172、rs10216767、rs1583300、rs281708、rs10955457、rs10103715、rs281673、rs439896、rs281685、rs281696、rs2014769、rs281740及びrs190735、並びにNCBI(v36.1)108394240からなる群より選択され、
ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs3869296、rs7020465、rs11142449、rs11142461、rs10868851、rs13439981、rs7039076、rs265083、rs2131355、rs265087、rs265073、rs7861495、rs10869020、rs17085775、rs11795256、rs10869034、rs1411992、rs10869043、rs12343877、rs11142941、rs869950、rs7046236及びrs9644996からなる群より選択され、
ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs3012514、rs7846808、rs7027640、rs10781101、rs4526421、rs7853275、rs10869178、rs7864535、rs12004208、rs6560277、rs4573342、rs4132905、rs4073227、rs10121866、rs7044241、rs7855743、rs4373587、rs11143314、rs7047875、rs6560284、rs6560285、rs7857300、rs6560287、rs7866185、rs6560293、rs7026124、rs12346185、rs7041300、rs4307407、rs17095、rs10113863、rs7029452、rs6560297、rs7045535、rs13285932、rs10521449、rs13285999、rs10869190、rs9314799、rs1037031、rs2487471、rs2589623、rs2793153、rs2589615、rs969205、rs1796991、rs1838487、rs2589609、rs1663756、rs12351661、rs1663763、rs13298704及びrs2501914からなる群より選択され、
ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs6479357、rs9409602、rs10991978、rs10991988、rs7867934、rs1388966、rs902923、rs902922、rs10512215、rs1532230、rs12337820、rs7029450、rs2131304、rs10992027、rs9299395、rs1388967、rs4073736、rs4073735、rs9409652、rs10992075、rs7031729、rs17585790、rs16907725、rs16907728、rs4372069、rs16907761、rs16907764、rs17586213、rs7039620、rs16907768、rs10992090、rs3802379、rs3935382、rs4601388、rs4744101、rs4743852、rs10119449、rs7858240、rs7022147、rs1569141、rs10992124、rs7856144、rs7855417、rs6479374、rs1881385、rs16907863、rs12002851、rs1881392、rs10992137、rs7045226、rs11789730、rs16907923、rs12684524、rs7858435、rs10116326、rs16907979、rs10992161、rs6479386、rs3858082、rs7038823、rs7871522、rs10125466、rs10992178、rs10820926、rs6479389、rs10820927、rs7867072、rs1954599及びrs10992207からなる群より選択され、
ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs7022663、rs7024526、rs2289631、rs10986505、rs16927802、rs12001999、rs10819019、rs6478690、rs1017530、rs3824507、rs12352758、rs4838242、rs650599、rs7860360、rs2113352、rs7019234、rs7867749、rs2271746、rs16927930、rs10986618、rs10986626、rs12237026、rs463774、rs420423、rs10986641、rs10513445、rs393721、rs10819043、rs10986689、rs10986698、rs10986703、rs10986714、rs10986715、rs10986721、rs10986722、rs1463837、rs4837016、rs10126025、rs10986738、rs2819624及びrs3122938からなる群より選択され、
ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs17306253、rs10887498、rs12243608、rs1876887、rs2457451、rs2664403、rs2664394、rs1912274、rs1912322、rs744413、rs2664406、rs2664405、rs2616673、rs2175200、rs2175201、rs17105725、rs1912277、rs2457450、rs17105747、rs746992、rs7076174、rs4027581、rs11201743、rs4418740、rs17105793、rs12221324、rs17105805、rs7924009、rs11201759、rs11201775、rs3011700、rs2949380、rs17105842、rs3011704、rs2140661、rs1917136、rs17105866、rs1880389、rs884316、rs2949384、rs2949385、rs2140666、rs2949386、rs1106789、rs11201804、rs17105912、rs17105916、rs2352181、rs947596、rs2352099、rs7924131、rs7923188、rs7923344、rs1418396、rs7899222、rs10788472、rs10887538、rs2153828、rs7910835、rs7914815、rs7918491、rs2001417、rs2001416、rs10887540、rs7095652、rs12773130、rs12779841、rs10887544、rs11201871、rs10887549、rs10788476、rs2003111、rs7912451、rs11201882、rs2352178、rs7923926、rs7082134、rs4284352、rs6585995、rs6585996、rs5003944、rs7923310、rs884700、rs4934156、rs11201909、rs868042、rs12257526、rs12262754、rs11817682、rs12243396、rs1870156、rs2607830、rs17320915、rs2814322、rs2607840、rs11201944、rs17106434、rs2607822、rs10887563、rs10887564、rs2492738、rs1870161、rs2607839、rs1870165、rs2814340、rs1902678、rs2814349、rs1947567、rs2168725、rs1902680、rs2607833、rs1902676、rs1896527、rs6586003、rs12262612、rs6586004、rs17106584、rs7905184、rs10887578、rs10509530、rs1078789、rs10749537、rs12355013、rs7904985、rs10788500、rs10788501、rs10458771、rs2018507、rs10887608、rs4934207、rs4934208及びrs7083506からなる群より選択され、
ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs7124648、rs7128650、rs4587689、rs11039097、rs12796744、rs17197619、rs17790390、rs11039105、rs10501319、rs11039112、rs747650、rs7937410、rs17197710、rs1685404、rs2013867、rs901746、rs7118396、rs10838681、rs10501321、rs1051006、rs3816724、rs7124955、rs4752824、rs1052373、rs11570094、rs10769255、rs11039212、rs4992357、rs11605672、rs1534576、rs10742805、rs12419692、rs4752856、rs3817334、rs7120548、rs10838739、rs11039329、rs10742817、rs4752791、rs17788930、rs7114011、rs10838774、rs2305982、rs6485788、rs10838782、rs7924699、rs1872167、rs747782及びrs1681630からなる群より選択され、
ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10896302、rs17615246、rs10750820、rs1945245、rs3938998、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs1945213、rs1945211、rs7113069、rs11228306、rs12785840、rs10501353、rs1945203、rs585475、rs615231、rs617315、rs675991、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594、rs634955及びrs613050からなる群より選択され、
ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs1026250、rs10750931、rs7126121、rs11230241、rs10897026、rs12225299、rs10792264、rs7125753、rs11605188、rs1899571、rs11230258、rs11230261、rs7943967、rs4442568、rs10897047、rs2868121、rs7945665、rs10897049、rs4506675、rs10792267、rs2304935、rs2165832、rs10736703、rs4939347、rs2233244、rs950803、rs950802、rs3816270、rs2241920、rs10501383、s10897056、rs4939352、rs955019、rs4938943、rs11230304、rs3763850、rs2282524、rs10897061、rs2120182、rs12787520、rs4146870、rs4939364、rs1051756、rs1941032、rs17615252、rs17543397、rs8181503、rs7946021、rs4939391、rs2186919、rs2847222、rs2633277及びrs2847212、並びにNCBI(v36.1)59954904からなる群より選択され、
ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs565976、rs534179、rs2276443、rs532454、rs511190、rs566818、rs482458、rs1793412、rs1790149、rs1790155、rs1790154、rs668727、rs11600640、rs611449、rs11236449、rs661928、rs621305、rs11236452、rs7128888、rs7129014、rs688727、rs674503、rs606452、rs11236458、rs599816、rs660343、rs541993、rs601142、rs648930、rs611221、rs12574551、rs584046、rs640927、rs11236476、rs17134231、rs12282340、rs10160335、rs12281880、rs656007、rs479592、rs589443、rs4944086、rs10751245、rs7110142、rs7947980及びrs509530、並びにNCBI(v36.1)75005360からなる群より選択され、
ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs17120344、rs6589597、rs10790175、rs12420127、rs10892082、rs7107152、rs1242229、rs1784042、rs2269399、rs526602、rs664971、rs11216315、rs1263499、rs17120523、rs236919、rs528508、rs593245及びrs477036、並びにNCBI(v36.1)116617736からなる群より選択され、
ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs7297299、rs5745807、rs5745811、rs9739560、rs4767654、rs10638、rs9788041、rs11068799、rs11068803、rs10850953、rs7135008、rs11613924、rs7307331、rs9669474、rs7957463、rs10850956、rs2936840、rs904661、rs1726407、rs1726392、rs17440336、rs1277442、rs11068860、rs11068865、rs17512142、rs17440364、rs364823、rs418941、rs7974718、rs11068891、rs16948230、rs404566、rs16948234、rs17512483、rs17512574、rs2271007、rs11068937、rs7966814、rs6490178、rs905579、rs983421、rs1503767、rs7132650及びrs7316050からなる群より選択され、
ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7964173、rs11061064、rs10848174、rs7965385、rs7979388、rs7953972、rs4759749、rs4759751、rs7308461、rs1881062、rs10083153、rs729463、rs1881067、rs2695872、rs10848193、rs10848194、rs7305915、rs2398529、rs3864899、rs4412792、rs2632601、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483、rs1609985、rs10848218、rs11061198、rs7307055、rs11061209、rs10773833、rs11061222、rs7299940、rs2141182、rs1405904、rs1316893、rs4074922及びrs4388928からなる群より選択され、
ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs9521809、rs4773201、rs1106649、rs9521814、rs385037、rs7997619、rs912941、s1886871、rs2182271、rs912942、rs331596、rs9559844、rs331602、rs1536621、rs9521853、rs9559849、rs7999854、rs3858821、rs4771696、rs4773228、rs4773229、rs2765341、rs3742193、rs3742194、rs7323602、rs3759463、rs179356、rs330565、rs7394、rs389656、rs450514、rs445490、rs418321、rs2251314、rs2165418、rs7999702、rs9521926、rs3098728、rs9515279及びrs2582886、並びにNCBI(v36.1)110097814からなる群より選択され、
ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs6493469、rs12595526、rs8031702、rs17599974、rs16953045、rs10744956、rs2306335、rs6493470、rs7181201、rs11856609、rs1124769、rs17647040、rs12899586、rs12904155、rs7170455、rs7177664、rs8040954、rs17647084、rs4775916、rs1111266、rs16964077、rs1025738、rs7179084、rs7176579、rs16964113、rs10519293、rs17522553、rs12324478、rs1075681、rs2899469、rs8031580、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs16964201、rs12595627、rs8023263、rs2899473、rs700518、rs3759811、rs17703883、rs1865803、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs1062033、rs2008691、rs11636403、rs10519299、rs17647707、rs17647719、rs7167343、rs936308、rs12594203、rs999480、rs2290622、rs8031463、rs6493495、rs2445765、rs2445766、rs2445768、rs1551656、rs12441382、rs2446420、rs2124873、rs2470184、rs2470187、rs2445781、rs12595284、rs17647970、rs7174434、rs764530、rs12438104、rs16964308、rs4775942、rs16964316、rs2470172、rs2470173、rs16964319、rs10163098、rs12443092、rs2168623、rs3751586、rs2445741、rs8036694、rs2459396及びrs16964348、並びにNCBI(v36.1)49383121からなる群より選択され、
ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs4399573、rs12051837、rs6504736、rs7208167、rs9303589、rs1468118、rs10491154、rs17695254、rs2073864、rs9912472、rs3764798、rs17695921、rs11867674、rs886078、rs8076197、rs8076496、rs2073866、rs9901183、rs4794293、rs8064617、rs4794294、rs985758、rs4794295、rs16950363、rs2873938、rs1263962、rs1263965、rs1263988、rs1263989、rs4794298、rs4794300、rs8080331、rs11869209、rs1269480、rs1263978、rs1003290、rs1263981、rs1405191、rs1263984、rs9904076、rs4794304、rs8074185、rs6504747、rs16950512、rs7223782、rs4794305、rs16950534、rs1526182、rs1501255、rs4496207、rs1125750、rs1405187、rs767326、rs981577、rs4794307、rs202133、rs16950626、rs9896969、rs202136、rs202121、rs202120、rs203076、rs203090、rs203092、rs203093、rs203097、rs203098、rs10514990、rs203010、rs10514991、rs203022、rs6504754、rs12603762、rs169386、rs203042、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs203002、rs1005092、rs9896168、rs8065627、rs16950939、rs2907784、rs11079991、rs1393735、rs2970016、rs1875675、rs2938139、rs1354275、rs7224915、rs9893317、rs1503059、rs2970052、rs11655715、rs1155218、rs2931368、rs2931365、rs2931364、rs9908649、rs1486745、rs4605214、rs1503041、rs10514997、rs10514998、rs11079993、rs1503050、rs1503051、rs10515000、rs12949235、rs1393734、rs17678475、rs16951169、rs12150128、rs16951176、rs16951177、rs9903651、rs10515001、rs1847245、rs12150499及びrs6504764からなる群より選択され、
ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs8086948、rs12457951、rs11151371、rs17077389、rs1480679、rs5000099、rs1480682、rs433411、rs370944、rs395074、rs379982、rs281571、rs1444106、rs2448716、rs1562072、rs1867412、rs17077583、rs764133、rs17828615、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112、rs2448755、rs2448745、rs2440527、rs28379561、rs10503118、rs1562070、rs2448727、rs17077858、rs12605273、rs2440540、rs4127445、rs7231324、rs12964913、rs9319739、rs17077963、rs12954315、rs4127447、rs7243836、rs8085641、rs2054299、rs515540、rs519360、rs17078114、rs2613163、rs652082、rs638006、rs3911662、rs12966846、rs3845265、rs11661918、rs11151403及びrs9953435からなる群より選択され、
ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs1884029、rs6072606、rs2207220、rs4812571、rs4572656、rs2013923、rs4812574、rs6513762、rs6513763、rs6029950、rs2144009、rs2866941、rs6102658、rs2144011、rs3787282、rs746413、rs4812578、rs6102671、rs1126101、rs6065434、rs4810352、rs1076666、rs6029980、rs6016688、rs2076249、rs17221018、rs17221067、rs17312515、rs17221137、rs6130047、rs16986551、rs17221326、rs16986558、rs12625871、rs6016698、rs6030014、rs17221823、rs1883377、rs6016705、rs2179336、rs2143008、rs6030030、rs2206169、rs6102713、rs6093598、rs6030070、rs6030071、rs1014757、rs2143632、rs6030076、rs16986712、rs727337、rs727336、rs6030096、rs11906485、rs2867026、rs16986733、rs11698118、rs6124439、rs11696306、rs1016071、rs6030124、rs1573707、rs6016745、rs12481463、rs4812588、rs6102795、rs11697499、rs4812591、rs916327、rs1883269、rs16986850、rs1033414、rs11700137、rs6072747、rs999114、rs999113、rs6016798、rs2076082、rs6065482、rs6065484、rs6065487、rs6130145、rs230153、rs230154、rs172981、rs230155、rs6072758、rs230157、rs6124468、rs6102880、rs6130153、rs6065504、rs6065509、rs6072789、rs1033643、rs13040647、rs16987042、rs6030322、rs6072792、rs4482557、rs6130168、rs6030341、rs17747544、rs6065515、rs1883843、rs8119203、rs10854226、rs6102929、rs8121443、rs6030363、rs6102950、rs2867488、rs7360934、rs909863、rs6030370、rs6030380、rs6030381、rs9974028、rs6093705、rs6030385、rs6102967、rs2223542、rs6030395、rs6065520、rs6072814、rs2206426、rs6016864、rs6072819、rs6030407、rs6065525、rs2425520、rs2425530、rs4812631、rs4810366、rs2017914、rs3092557、rs17749109、rs4812637、rs6030442、rs6030443、rs1018407、rs6016884、rs1022819、rs733976、rs6030456、rs6093729、rs6030462、rs17749217、rs2146615、rs8119733、rs13042473、rs6103041、rs1973949、rs208256、rs208254、rs3092043、rs2077768、rs208250、rs4812645、rs6130222、rs4812655、rs6130232、rs208230、rs208229、rs6065544、rs6065545、rs6065546、rs7262282、rs7262355、rs11699742、rs8125304、rs6065547、rs4812659、rs16987493、rs208272、rs208273、rs4315585、rs208186、rs208197、rs206636、rs6030572、rs4812664、rs4812665、rs16987668、rs206148、rs206154、rs206159、rs206163、rs2208048、rs2425546、rs2425553、rs2425554、rs2425560、rs2425562、rs1106978、rs6030634、rs6016951、rs1006746、rs2425587、rs927058、rs2425593、rs2425599、rs2425610、rs16987770、rs6016963、rs6065579、rs1572929、rs6072998、rs6030670、rs947202、rs947203、rs4812681、rs6093784、rs4812683、rs10485698、rs926288、rs1569445、rs6030689、rs2867656、rs11699547、rs6030709及びrs7267873、並びにNCBI(v36.1)40130174からなる群より選択され、
ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs12626309、rs2834231、rs4817579、rs2834238、rs2211689、rs2834246、rs2834251、rs2834252、rs1537097、rs1892589、rs2073368、rs2409499、rs9978415、rs2268247、rs9979937、rs2834264、rs2834268、rs879261、rs2245099、rs1108000、rs9979150、rs743316、rs2300384、rs3746861、rs2834292、rs2834295、rs2040113、rs2834296、rs2834297、rs2239565、rs17655810、rs12626410、rs2834303、rs2236645、rs2834310、rs16991110、rs2070513、rs2032312、rs2032313、rs2834315、rs11088265、rs17730050及びrs2834332からなる群より選択され、
ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs13416802、rs2287616、rs2287613、rs3770597、rs10200158、rs6761690、rs13430236、rs3814381、rs4148765、rs10490134、rs11902639、rs10183805、rs13403114、rs3815574、rs2302698、rs6750251、rs4667590、rs4668121、rs1990702、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs11679947、rs10490132、rs2239602、rs2024481、rs741378、rs2284679、rs4287730、rs10210408、rs1548936、rs3770604、rs2075248、rs10490131、rs10169232、rs2239600、rs2284675、rs2268373、rs2268372、rs2193193、rs2268370、rs6747692、rs2300445、rs2239598、rs2239597、rs2239596、rs2239594、rs830957、rs830959、rs12988804、rs831002、rs16856748、rs11887007、rs16856759、rs830964、rs830971、rs830972、rs2247506、rs3845731、rs3770636、rs2673172、rs6713072、rs1990842、rs10199676、rs830955、rs12616998、rs12613663、rs10930354、rs4281872及びrs12052892からなる群より選択され、
ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs523246、rs10501136、rs836950、rs12808574、rs10836315、rs502857、rs731726、rs731727、rs967751、rs1553760、rs1396880、rs2941043、rs2941042、rs2941061、rs2956079、rs2941054、rs1509662、rs2941052、rs2915234、rs891550、rs919554、rs2915232、rs2956086、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986425、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs984690、rs3763934、rs10488801、rs2956106、rs11032927、rs2915202、rs2915201、rs2915199、rs1998912、rs2915193、rs11032937、rs2915227、rs2732557、rs10836326、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs1409716、rs2762955、rs952489、rs514182、rs1425806、rs2732528、rs2553794、rs2553793、rs678137、rs2785156、rs2553787、rs737503、rs737502、rs2162159、rs2732552、rs387619、rs10836332、rs353610、rs353605、rs2785189、rs2553822、rs11032995、rs12291631、rs353590、rs353589、rs353587、rs1559759、rs4756190、rs353581、rs7106681、rs507230、rs634096、rs2732578、rs404977、rs4756191及びrs2785180からなる群より選択され、
ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs7979656、rs10849918、rs2106407、rs2106406、rs12425190、rs11065783、rs2339706、rs4509829、rs7961663、rs4766526、rs4766442、rs4766443、rs12815195、rs12229654、rs756825、rs16941284、rs6489979、rs4766553、rs9783423、rs7952972、rs16941319、rs3809290、rs7962233、rs4766451、rs886126、rs2078851、rs1265566、rs2301658、rs7300082、rs7300860、rs16941414、rs7398833、rs16941437、rs10849946、rs2078863及びrs11065898からなる群より選択され、
ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs2332297、rs2934884、rs16955216、rs2934890、rs7225247、rs16955225、rs9303359、rs7207731、rs17683089、rs11658131、rs2958944、rs2934909、rs2934914、rs2934921、rs2958933、rs7221313、rs7210248、rs2958921、rs8079105、rs16955327、rs12949718、rs9899602、rs17745123、rs8070668、rs9910653、rs17817829、rs12936860、rs12951898、rs17817950及びrs2787501、並びにNCBI(v36.1)50344775からなる群より選択される請求項１記載の検査方法。
【請求項３】
正常眼圧緑内障患者と健常者間での有意差をｐ値で表したとき、多型部位のｐ値が0.05未満を示す請求項１又は２記載の検査方法。
【請求項４】
ヒト第６染色体のELOVL5を含む領域における多型部位が、一塩基多型国際番号rs2817088、rs2817090、rs2816372、rs2562895、rs2816364、rs2562893、rs2817101、rs2816362、rs2816356、rs2562898、rs735860、rs2057024、rs1429146、rs9463895、rs2235723、rs1346603、rs9474476、rs2294867、rs9349660、rs974323、rs6909592、rs9367520、rs9395854、rs209485、rs9395856、rs7747926、rs7738788、rs209500、rs9357760、rs9370196、rs209512、rs209517、rs9370201l及びrs9367529からなる群より選択され、
ヒト第２染色体のSRBD1を含む領域における多型部位が、一塩基多型国際番号rs2343466、rs11888802、rs2343468、rs12471726、rs2081297、rs10460504、rs6719211、rs4455206、rs3755076、rs3770264、rs10205197、rs17033745、rs17322370、rs17033801、rs748573、rs6708810、rs6710581、rs17033871、rs3755082、rs11884064及びrs556650からなる群より選択され、
ヒト第３染色体のARPP-21を含む領域における多型部位が、一塩基多型国際番号rs12487524、rs872133、rs2197728、rs2359774、rs6799641、rs4678789、rs11129660、rs11129662、rs6779091、rs3772395、rs17228111、rs735353、rs11920715、rs1455489、rs4678509、rs10510667、rs6799649及びrs4234248からなる群より選択され、
ヒト第４染色体のEPHA5を含む領域における多型部位が、一塩基多型国際番号rs371925、rs4241661、rs2167320、rs1159057、rs12501311、rs17086016、rs961489、rs7684130、rs3749526、rs11938753、rs7658065、rs17082122、rs4289492、rs9991256、rs7660334及びrs4604104からなる群より選択され、
ヒト第６染色体のGMDSを含む領域における多型部位が、一塩基多型国際番号rs2438083、rs7744559、rs9378292、rs2569866、rs11242704、rs2816286、rs2816287、rs2317965、rs2873591、rs2569835、rs2745567、rs2493160、rs1810496、rs12197419、rs2318108、rs6919059、rs17134506、rs3800142、rs3800146、rs10223785、rs6596866、rs4959621、rs4412249、rs4367413、rs11242729、rs6925298、rs9392353、rs11242730、rs4580917、rs11242733、rs11242735、rs476594、rs9378676、rs676015、rs2026446、rs4959631、rs11242740、rs3778557、rs234930、rs234915、rs234914、rs3800184、rs234932、rs3778568、rs9405550、rs3823287、rs1196396、rs1684153、rs9328087、rs2479003、rs2479004、rs2505678、rs2479008、rs2505674、rs7766115、rs4959648、rs7449538、rs6902556、rs6925653及びrs6904395からなる群より選択され、
ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域における多型部位が、一塩基多型国際番号rs2077102、rs805301、rs2242655、rs707918、rs805292、rs2299851、rs707939、rs480092、rs2075800、rs2763979及びrs11965547からなる群より選択され、
ヒト第６染色体のSYTL3を含む領域における多型部位が、一塩基多型国際番号rs6455585、rs6931414、rs6925091、rs6913912、rs894124、rs6455601及びrs3123094からなる群より選択され、
ヒト第７染色体のNXPH1を含む領域における多型部位が、一塩基多型国際番号rs10246412、rs17404198、rs17149337、rs17404218、rs11976158、rs6978212、rs10261060、rs4401754、rs10278603、rs7787432、rs10237485及びNCBI(v36.1)8484291からなる群より選択され、
ヒト第７染色体のLHFPL3を含む領域における多型部位が、一塩基多型国際番号rs7794181、rs11763758、rs756669、rs4730038、rs4584085、rs17141284、rs17141299及びNCBI(v36.1)104196627からなる群より選択され、
ヒト第１１染色体のGLB1L3を含む領域における多型部位が、一塩基多型国際番号rs11223704、rs1146192、rs1144219、rs2510356及びrs1866768からなる群より選択され、
ヒト第１８染色体のZNF407を含む領域における多型部位が、一塩基多型国際番号rs514931及びrs10871527からなる群より選択され、
ヒト第１染色体のPAX7を含む領域における多型部位が、一塩基多型国際番号rs2298893、rs685300及びrs2056446からなる群より選択され、
ヒト第１染色体のPTPRFを含む領域における多型部位が、一塩基多型国際番号rs6687571、rs2039528、rs10890251、rs10890257、rs12058744、rs11210879、rs10789438、rs11210892、rs617521及びrs10789439からなる群より選択され、
ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域における多型部位が、一塩基多型国際番号rs2355388、rs6686200、rs12122453、rs12122534、rs517201、rs2031481、rs2477568、rs2477569、rs535827、rs6593732、rs17359526、rs6693631、rs11811023、rs4950371、rs2304893、rs6593739、rs7525703、rs2883434、rs17159914、rs6593745、rs6670503、rs6703187、rs10793652、rs7537483、rs7537703、rs3820130、rs3737845、rs4950315、rs10494244、rs6683839、rs10793656、rs17360443、rs12033407、rs10793661、rs10736837、rs10900336、rs4950409、rs10793682、rs11240055、rs17160256、rs17160264及びrs17160305からなる群より選択され、
ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域における多型部位が、一塩基多型国際番号rs11265310、rs16836320、rs868108、rs4845390、rs1984285、rs11264339、rs3768566、rs11264345、rs7520184、rs12032720、rs11264359、rs11264363、rs5005770、rs1325908、rs11264375、rs475550、rs821551、rs822490、rs822508、rs1749405、rs954916及びrs11590409からなる群より選択され、
ヒト第１染色体のFAM5B及び／又はASTN1を含む領域における多型部位が、一塩基多型国際番号rs227521、rs227519、rs10047146、rs10489307、rs1402640、rs10913291、rs10798503、rs725416、rs554454、rs10913300、rs760689、rs6683060、rs926319、rs6699955、rs10798508、rs2139876、rs17315298、rs2861972及びrs6672376からなる群より選択され、
ヒト第１染色体のPKP1を含む領域における多型部位が、一塩基多型国際番号rs1404401、rs16847944、rs1572968、rs12143423、rs6427900及びrs2275860からなる群より選択され、
ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域における多型部位が、一塩基多型国際番号rs12613333、rs2723129、rs1465677、rs1864807、rs1864808、rs497973及びrs3806510からなる群より選択され、
ヒト第３染色体のTHRBを含む領域における多型部位が、一塩基多型国際番号rs1397878、rs6808673、rs17194828、rs9310730、rs7652444、rs4858594、rs17787319、rs1505307、rs7640580、rs9833191、rs3951794及びrs5014281からなる群より選択され、
ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域における多型部位が、一塩基多型国際番号rs1993404、rs16863149、rs16863204、rs16863208、rs3732755、rs3773614、rs9820422、rs1388622及びrs4680474からなる群より選択され、
ヒト第４染色体のSORBS2を含む領域における多型部位が、一塩基多型国際番号rs10015164、rs10024359、rs11940307、rs2648120、rs2648117、rs4861686、rs4637445、rs2278938、rs12641600、rs4862600及びrs10002339からなる群より選択され、
ヒト第５染色体のMAST4を含む領域における多型部位が、一塩基多型国際番号rs16895719、rs16895744、rs37568、rs16896071、rs39664、rs469300、rs467845及びNCBI(v36.1)65944399からなる群より選択され、
ヒト第５染色体のGLRX及び/又はC5orf27を含む領域における多型部位が、一塩基多型国際番号rs6876015、rs11135436、rs6884979、rs7702848、rs2080947及びNCBI(v36.1)95206085からなる群より選択され、
ヒト第５染色体のEBF1を含む領域における多型部位が、一塩基多型国際番号rs1541649、rs2116727、rs10067813、rs7709065、rs10070743、rs10056564、rs6556373、rs4921537、rs1544754、rs17056426、rs1363561、rs1422672、rs10515787及びrs10515786からなる群より選択され、
ヒト第５染色体のDOCK2を含む領域における多型部位が、一塩基多型国際番号rs7729471、rs261039、rs2291229、rs17646198、rs17560405、rs261006、rs155023、rs259900、rs13152920、rs11134603及びrs10462995からなる群より選択され、
ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域における多型部位が、一塩基多型国際番号rs10484565、rs9276825、rs188245、rs6457710、rs455567、rs211453、rs2772376、rs9469491、rs9296095、rs498114、rs654682、rs10947432、rs943466、rs755495、rs747692、rs943475、rs6929696、rs3828783及びrs9366829からなる群より選択され、
ヒト第６染色体のLOC100132919を含む領域における多型部位が、一塩基多型国際番号rs9377361、rs9322660、rs9322661、rs2399802、rs680011、rs9499111、rs1569366、rs1569367及びrs6906578からなる群より選択され、
ヒト第７染色体のAAA1及び/又はNPSR1を含む領域における多型部位が、一塩基多型国際番号rs12673387、rs6950303、rs1034876、rs17169864、rs17169865、rs16878959、rs10486649、rs12672538、rs450463、rs2530548、rs2530549、rs2530550、rs1458544、rs323925及びrs323912からなる群より選択され、
ヒト第７染色体のELMO1を含む領域における多型部位が、一塩基多型国際番号rs4720221、rs2392472、rs17170754、rs3807162及びrs11982286からなる群より選択され、
ヒト第８染色体のTNKSを含む領域における多型部位が、一塩基多型国際番号rs1466338、rs6991328、rs17150131、rs7817148、rs7016636、rs6985564、rs4840426、rs7832096、rs13273033、rs4841200、rs7459728、rs7461939、rs9644708、rs12545912、rs4840437、rs7004915、rs7820917、rs7829463、rs17734290、rs13270146、rs6601389、rs6601390、rs10098618、rs12056944、rs12543996及びrs7828229からなる群より選択され、
ヒト第８染色体のANGPT1を含む領域における多型部位が、一塩基多型国際番号rs16876200、rs2514867、rs11785702、rs1283663、rs1283694、rs1433192、rs1433191及びrs10216767からなる群より選択され、
ヒト第９染色体のPGM5を含む領域における多型部位が、一塩基多型国際番号rs7020465、rs10868851、rs7039076、rs2131355、rs265073、rs7861495、rs10869020、rs11795256、rs10869034、rs1411992、rs10869043及びrs12343877からなる群より選択され、
ヒト第９染色体のTMC1を含む領域における多型部位が、一塩基多型国際番号rs7027640、rs12004208、rs6560277、rs7044241、rs4373587、rs11143314、rs7047875、rs7866185、rs7026124、rs12346185、rs7041300、rs4307407、rs10113863、rs7029452、rs7045535、rs13285932、rs10521449、rs1037031及びrs2487471からなる群より選択され、
ヒト第９染色体のROR2を含む領域における多型部位が、一塩基多型国際番号rs10119449、rs7022147、rs7856144、rs6479374、rs1881385及びrs7045226からなる群より選択され、
ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域における多型部位が、一塩基多型国際番号rs1017530、rs7860360、rs2113352、rs7019234、rs2271746、rs10986618、rs10986626、rs10513445、rs10986703及びrs10986738からなる群より選択され、
ヒト第１０染色体のGRID1を含む領域における多型部位が、一塩基多型国際番号rs2202925、rs11201743、rs17105793、rs17105805、rs11201775、rs10887549、rs10788476及びrs4284352からなる群より選択され、
ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域における多型部位が、一塩基多型国際番号rs11039112、rs747650、rs1685404、rs11570094、rs11039212、rs4992357、rs11605672、rs10742805、rs12419692、rs4752856、rs3817334、rs4752791、rs17788930、rs2305982、rs6485788、rs7924699及びrs1872167からなる群より選択され、
ヒト第１１染色体のOR5R1を含む領域における多型部位が、一塩基多型国際番号rs1586004、rs7940239、rs10791979、rs1573511、rs12277883、rs7116573、rs10896333、rs4420287、rs1894026、rs7113069、rs11228306、rs10501353、rs1945203、rs615231、rs7939886、rs4939052、rs621957、rs611534、rs594854、rs618594及びrs634955からなる群より選択され、
ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域における多型部位が、一塩基多型国際番号rs4939347、rs2233244、rs3816270、rs2241920、rs10501383、s10897056及びrs4939352からなる群より選択され、
ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域における多型部位が、一塩基多型国際番号rs482458、rs661928、rs7128888、rs7129014、rs688727、rs12574551、rs17134231、rs12282340、rs10160335及びrs12281880からなる群より選択され、
ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む)を含む領域における多型部位が、一塩基多型国際番号rs664971、rs17120523及びrs528508からなる群より選択され、
ヒト第１２染色体のTAOK3を含む領域における多型部位が、一塩基多型国際番号rs10850953、rs1726392、rs17440336、rs17512142、rs17440364、rs16948230、rs16948234、rs17512483及びrs17512574からなる群より選択され、
ヒト第１２染色体のSTX2を含む領域における多型部位が、一塩基多型国際番号rs7305915、rs3864899、rs1554807、rs10848205、rs2037789、rs4619189、rs2001483及びrs1405904からなる群より選択され、
ヒト第１３染色体のCARS2を含む領域における多型部位が、一塩基多型国際番号rs4773201、rs450514、rs445490、rs418321及びrs2251314からなる群より選択され、
ヒト第１５染色体のCYP19A1を含む領域における多型部位が、一塩基多型国際番号rs12595526、rs1124769、rs17647040、rs7170455、rs7177664、rs8040954、rs8029120、rs4774583、rs2289105、rs8034835、rs6493489、rs8023263、rs700518、rs3759811、rs4775936、rs10459592、rs17523270、rs10519297、rs11636686、rs11636667、rs11636403、rs10519299、rs2445765、rs12441382、rs2446420、rs2445781、rs7174434、rs12438104、rs4775942及びrs16964316からなる群より選択され、
ヒト第１７染色体のCA10を含む領域における多型部位が、一塩基多型国際番号rs4794268、rs4794274、rs12051837、rs6504736、rs4496207、rs9896969、rs203076、rs203090、rs203092、rs12603762、rs169386、rs7215008、rs996379、rs4794315、rs1501253、rs203050、rs1005092及びrs9896168からなる群より選択され、
ヒト第１８染色体のLOC643542を含む領域における多型部位が、一塩基多型国際番号rs433411、rs370944、rs395074、rs281571、rs2448716、rs2440515、rs10503119、rs2318439、rs12607172、rs9319737、rs1444112及びrs17077963からなる群より選択され、
ヒト第２０染色体のPTPRTを含む領域における多型部位が、一塩基多型国際番号rs4572656、rs16986733、rs6016745、rs6016798、rs6065487、rs6130145、rs230153、rs230155、rs6072758、rs8119203、rs6030395、rs2425530、rs4812637、rs6030456、rs927058、rs2425593、rs16987770、rs6065579、rs6072998、rs6030670、rs947202、rs947203及びrs6093784からなる群より選択され、
ヒト第２１染色体のITSN1を含む領域における多型部位が、一塩基多型国際番号rs2834268、rs9979150、rs2300384、rs3746861、rs2834292、rs2834303及びrs2236645からなる群より選択され、
ヒト第２染色体のLRP2を含む領域における多型部位が、一塩基多型国際番号rs4668121、rs6746604、rs990627、rs990626、rs2268380、rs6733122、rs2284681、rs2239602、rs741378、rs10210408、rs1548936、rs3770604、rs2075248、rs10169232、rs2239600、rs2284675、rs2268370、rs6747692、rs2239596、rs830957、rs830959、rs12988804、rs831002、rs1990842及びrs10199676からなる群より選択され、
ヒト第１１染色体のAPIP及び/又はPDHXを含む領域における多型部位が、一塩基多型国際番号rs836950、rs12808574、rs10836315、rs1998603、rs2985390、rs1571134、rs1571135、rs2915224、rs1430855、rs2985389、rs3751078、rs2915223、rs2915220、rs2986427、rs1326940、rs1326941、rs1326942、rs2986429、rs2915217、rs7111607、rs2915214、rs3763934、rs10488801、rs2956106、rs11032927、rs1998912、rs2915193、rs11032937、rs2915227、rs2767038、rs10488806、rs2732564、rs2732565、rs2767033、rs952489及びrs353589からなる群より選択され、
ヒト第１２染色体のCUX2を含む領域における多型部位が、一塩基多型国際番号rs756825、rs4766553、rs3809290、rs4766451、rs886126、rs1265566、rs2301658及びrs7300082からなる群より選択され、
ヒト第１７染色体のTOM1L1を含む領域における多型部位が、一塩基多型国際番号rs17817829、rs12951898、rs17817950及びNCBI(v36.1)50344775からなる群より選択される請求項３記載の検査方法。
【請求項５】
正常眼圧緑内障の検査をするための試薬であって、下記の(a)及び(b)の成分からなる群より選択される少なくとも１つの成分を含む前記試薬。
(a) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位（但し、一塩基多型国際番号rs3213787及びrs17832851を除く）を含む領域を増幅することができるプライマー
(b) ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位（但し、一塩基多型国際番号rs3213787及びrs17832851を除く）を含む領域にハイブリダイズすることができるプローブ
【請求項６】
請求項５記載の試薬を含む、正常眼圧緑内障の検査キット。
【請求項７】
ヒト第６染色体のELOVL5を含む領域、ヒト第２染色体のSRBD1を含む領域、ヒト第３染色体のARPP-21を含む領域、ヒト第４染色体のEPHA5を含む領域、ヒト第６染色体のGMDSを含む領域、ヒト第６染色体の6p21.3（HSPA1Bを含む）を含む領域、ヒト第６染色体のSYTL3を含む領域、ヒト第７染色体のNXPH1を含む領域、ヒト第７染色体のLHFPL3を含む領域、ヒト第１１染色体のGLB1L3を含む領域、ヒト第１８染色体のZNF407を含む領域、ヒト第１染色体のPAX7を含む領域、ヒト第１染色体のPTPRFを含む領域、ヒト第１染色体の1q12-q21.1（CHD1L及び／又はFMO5を含む）を含む領域、ヒト第１染色体の1q21.2-q21.3（FDPS及び／又はASH1L及び／又はKCNN3を含む）を含む領域、ヒト第１染色体のFAM5B及び／又はASTN1を含む領域、ヒト第１染色体のPKP1を含む領域、ヒト第２染色体のKLHL29及び/又はFLJ14126を含む領域、ヒト第３染色体のTHRBを含む領域、ヒト第３染色体のMED12L及び／又はCLRN10S及び／又はGPR171を含む領域、ヒト第４染色体のSORBS2を含む領域、ヒト第５染色体のMAST4を含む領域、ヒト第５染色体のGLRX及び/又はC5orf27を含む領域、ヒト第５染色体のEBF1を含む領域、ヒト第５染色体のDOCK2を含む領域、ヒト第６染色体の6p21.31-p21.3（HLA-DPA1を含む）を含む領域、ヒト第６染色体のLOC100132919を含む領域、ヒト第７染色体のAAA1及び/又はNPSR1を含む領域、ヒト第７染色体のELMO1を含む領域、ヒト第８染色体のTNKSを含む領域、ヒト第８染色体のANGPT1を含む領域、ヒト第９染色体のPGM5を含む領域、ヒト第９染色体のTMC1を含む領域、ヒト第９染色体のROR2を含む領域、ヒト第９染色体のPPP6C及び/又はC9orf126を含む領域、ヒト第１０染色体のGRID1を含む領域、ヒト第１１染色体の11p11.2（SPI1及び／又はSLC39A13及び／又はPSMC3及び／又はRAPSN及び／又はNUP160を含む）を含む領域、ヒト第１１染色体のOR5R1を含む領域、ヒト第１１染色体のMS4A7及び/又はMS4A14を含む領域、ヒト第１１染色体のMAP6及び／又はGDPD5及び／又はSERPINH1を含む領域、ヒト第１１染色体の11q23-24(PCSK7及び／又はRNF214を含む) を含む領域、ヒト第１２染色体のTAOK3を含む領域、ヒト第１２染色体のSTX2を含む領域、ヒト第１３染色体のCARS2を含む領域、ヒト第１５染色体のCYP19A1を含む領域、ヒト第１７染色体のCA10を含む領域、ヒト第１８染色体のLOC643542を含む領域、ヒト第２０染色体のPTPRTを含む領域、ヒト第２１染色体のITSN1を含む領域、ヒト第２染色体のLRP2を含む領域、ヒト第１１染色体のAPIP及び/又はPDHXを含む領域、ヒト第１２染色体のCUX2を含む領域、並びにヒト第１７染色体のTOM1L1を含む領域からなる群より選択される少なくとも１個の領域における少なくとも１個の多型部位を含む最長１０００塩基長の連続したＤＮＡ部分配列又はその相補鎖からなるポリヌクレオチドを含む正常眼圧緑内障診断用マーカー遺伝子。
【請求項８】
請求項７記載のマーカー遺伝子のＤＮＡ配列を含有するベクター。
【請求項９】
請求項８記載のベクターで形質転換した宿主細胞。
【請求項１０】
請求項７記載のマーカー遺伝子のＤＮＡ配列を含有するベクターで形質転換した宿主細胞を培養し、培養物から請求項７記載のマーカー遺伝子のＤＮＡ配列がコードするポリペプチドを採取することを含む、ポリペプチドの製造方法。

【図１】

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【図１０】

【図１１】

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【図２１】

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【図３１】

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【図４１】

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【図５１】

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【公開番号】特開２０１０−１９３９０３（Ｐ２０１０−１９３９０３Ａ）
【公開日】平成２２年９月９日（２０１０．９．９）
【国際特許分類】
【出願番号】特願２０１０−１１０１６２（Ｐ２０１０−１１０１６２）
【出願日】平成２２年５月１２日（２０１０．５．１２）
【分割の表示】特願２００９−５９９３７（Ｐ２００９−５９９３７）の分割
【原出願日】平成２１年３月１２日（２００９．３．１２）
【出願人】（０００１３８０８２）株式会社メニコン (150)
【Ｆターム（参考）】